William Leonard Pickard is one of two people convicted in the largest lysergic acid diethylamide (LSD) manufacturing case in history. In 1999, while moving their LSD laboratory across Kansas, Pickard and Clyde Apperson were pulled over while driving a Ryder rental truck and a follow car. The laboratory had been stored near a renovated Atlas-E missile silo near Wamego, Kansas but the two men had never actually produced LSD there. One of the men intimately involved in the case but not charged due to his cooperation, Gordon Todd Skinner, owned the property where the laboratory equipment was stored.
The DEA has claimed that Pickard’s arrest led to a 95% drop in the availability of LSD in the US in the two years following the arrest, although this claim is refuted by Pickard and others.